Synonyms:

durena–by discarding it at a long distance; hi–certainly; avaram–abominable; karma–activities; buddhi-yogat–on the strength of Krsna consciousness; dhananjaya–O conqueror of wealth; buddhau–in such consciousness; saranam–full surrender; anviccha–desire; krpanah–the misers; phala-hetavah–those desiring fruitive action.

Translation:

O Dhananjaya, rid yourself of all fruitive activities by devotional service, and surrender fully to that consciousness. Those who want to enjoy the fruits of their work are misers.